RAPID COMMUNICATION Adenoviral E1A Protein Nuclear Import Is Preferentially Mediated by Importin a3 in Vitro
نویسندگان
چکیده
Nuclear import of some viral proteins depends on importin a proteins. However, no preferences of distinct a-importins for any viral protein import have been demonstrated. We used in vitro import assays and observed that all ubiquitously expressed human importin a isoforms mediate nuclear translocation of adenoviral E1A. Competition with nucleoplasmin suggests that importin a3 is the most efficient import mediator of E1A. © 2001 Academic Press
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